We extracted human-specific regulatory programmes that control the development of germline and somatic cell lineages by profiling equivalent developmental stages in mice. Here, we generated a comprehensive map of first- and second-trimester human gonads using a combination of single-cell and spatial transcriptomics, chromatin accessibility assays and fluorescent microscopy.
Historically, limited tissue accessibility, a lack of reliable in vitro models and critical differences between humans and mice have hampered our knowledge of human gonadogenesis, despite its importance in gonadal conditions and infertility. Gonadal development is a complex process that involves sex determination followed by divergent maturation into either testes or ovaries 1. Nature volume 607, pages 540–547 ( 2022) Cite this article Single-cell roadmap of human gonadal development
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